Kinase inhibition through gene edited cell lines

What Are Kinases?

Definition: Kinases are enzymes that mediate the transfer of phosphate groups to substrates. Phosphorylation of a substrate can alter its ability to interact with other molecules and its activity. For this reason kinases are important in numerous processes including; signalling, metabolism and transport among many others.

Overview of the kinase family

Kinases are a large family of enzymes with over 500 encoded in the human genome and all share a highly conserved kinase domain. Dependent on the substrate they act upon they can be broadly classified into 3 categories: protein kinases, carbohydrate kinases and lipid kinases. Due to the diverse roles that kinases play in the cell they are implicated in a number of diseases including cancer:

  • Protein kinases

    can phosphorylate substrate proteins on serine, threonine, tyrosines or histidine residues. Mitogen-activated protein kinases such as RAF kinases involved in the MAPK signalling pathways and cyclin dependent kinases (CDKs) involved in cell cycle regulation are prime examples of pathways implicated in cancers.
  • Lipid kinases

    alter the localisation and reactivity of lipids through phosphorylation. A well-known example of a lipid kinase is phosphoinositide 3-kinase which is implicated in a number of cancers, mainly through alterations to its catalytic subunit - PIK3CA.
  • Carbohydrate kinases

    such as hexokinase play important roles in the majority of metabolic pathways.
Available knockout
cell lines

Popular Knockout Cell Lines

AAK1 CLK1 HIPK2 MAPK9 PKN3 SRPK2
AATK CLK2 HIPK3 MAPKAPK2 PLK2 STK10
ABL2 CLK3 HUNK MAPKAPK3 PNCK STK16
ACVR1 CLK4 ICK MAPKAPK5 PRKAA1 STK17A
ACVR1B CSK IGF1R MARK1 PRKAA2 STK17B
ACVR2B CSNK1D IKBKB MARK2 PRKACA STK19
ADCK2 CSNK1E INSR MARK3 PRKACB STK25
ADCK3 CSNK1G1 IRAK1 MARK4 PRKCA STK3
ADCK4 CSNK1G2 IRAK2 MAST1 PRKCD STK32B
ADCK5 CSNK1G3 IRAK3 MAST2 PRKCE STK32C
ADRBK1 CSNK2A1 IRAK4 MAST3 PRKCG STK33
ADRBK2 CSNK2A2 ITK MAST4 PRKCI STK38
AKT1 DAPK1 JAK1 MATK PRKCQ STK38L
AKT2 DAPK2 JAK2 MELK PRKCZ STK39
ALK DAPK3 KIAA1804 MET PRKD1 STK4
ALPK1 DCLK2 KSR1 MINK1 PRKD2 STK40
ALPK2 DDR1 KSR2 MKNK1 PRKD3 STRADA
ARAF DDR2 LATS1 MKNK2 PRKG2 STRADB
AXIN1 DMPK LATS2 MLKL PRKX STYK1
AXL DSTYK LIMK2 MOK PSKH1 SYK
BCKDK DYRK1B LMTK2 MST4 PTK2B TAF1L
BCR DYRK2 LMTK3 MYLK PTK7 TAOK1
BMP2K DYRK3 LRRK1 MYLK3 PXK TAOK2
BMPR1A DYRK4 LRRK2 MYT1 RAF1 TAOK3
BMPR1B EEF2K LTK NEK1 RET TBCK
BMPR2 EIF2AK1 LYN NEK10 RIOK3 TBK1
BRD2 EIF2AK2 MAK NEK2 RIPK1 TEC
BRD3 EIF2AK3 MAP2K1 NEK3 RIPK2 TESK1
BRDT EIF2AK4 MAP2K2 NEK4 RNASEL TESK2
BRSK1 EPHA2 MAP2K3 NEK7 ROCK1 TGFBR1
BRSK2 EPHA3 MAP2K4 NEK8 ROCK2 TGFBR2
CAMK1D EPHA4 MAP2K5 NEK9 ROR1 TLK1
CAMK2D EPHA6 MAP2K6 NLK ROR2 TNIK
CAMK2G EPHB1 MAP2K7 NRBP2 RPS6KA1 TNK1
CAMKK1 EPHB2 MAP3K1 NTRK1 RPS6KA2 TRIB1
CAMKK2 EPHB3 MAP3K10 NUAK1 RPS6KA3 TRIB2
CAMKV EPHB4 MAP3K11 OBSCN RPS6KA4 TRIB3
CASK EPHB6 MAP3K12 OSR1 RPS6KA6 TRIO
CDC42BPA ERBB2 MAP3K14 PAK1 RPS6KB1 TSSK2
CDC42BPB ERBB3 MAP3K2 PAK2 RPS6KB2 TSSK3
CDC42BPG ERN1 MAP3K3 PAK4 RPS6KC1 TSSK4
CDK10 FASTK MAP3K4 PAK6 RPS6KL1 TTBK2
CDK13 FER MAP3K5 PASK RYK TWF2
CDK14 FES MAP3K6 PBK SBK1 TYK2
CDK16 FGFR2 MAP3K7 PDGFRA SCYL1 TYRO3
CDK17 FGFR3 MAP3K8 PDIK1L SCYL2 UHMK1
CDK18 FGFR4 MAP3K9 PDK1 SCYL3 ULK1
CDK19 FLT1 MAP4K3 PDK2 SGK223 ULK3
CDK2 FLT4 MAP4K4 PDK3 SGK3 ULK4
CDK3 FYN MAP4K5 PEAK1 SGK494 VRK1
CDK4 GAK MAPK1 PHKG1 SIK1 VRK2
CDK5 GRK4 MAPK11 PHKG2 SIK2 VRK3
CDK8 GRK5 MAPK12 PIM1 SIK3 WNK2
CDKL1 GRK6 MAPK15 PIM2 SLK WNK3
CDKL3 GSK3A MAPK3 PIM3 SNRK ZAK
CDKL5 GSK3B MAPK4 PINK1 SPEG  
CHEK2 HCK MAPK7 PKDCC SRC  
CHUK HIPK1 MAPK8 PKN1 SRPK1  
AGC
Subfamily
CAMK
Subfamily
CK1
Subfamily

CK1

Examples of available Knockout Cell Lines

CK1D CK1G2 SGK493 VRK1
CK1E CK1G3 SLOB VRK2
CK1G1 Haspin TTBK2 VRK3
CMGC
Subfamily
STE
Subfamily
TK
Subfamily
TKL
Subfamily

Our cell line range is constantly growing. For our most current list of ready-made cell lines and details of custom made engineering projects you can browse our entire offering via the link below.

Browse Our Cell Line Options


For offline access, many of our popular cell lines that are usually available for immediate delivery are listed in our downloadable our catalog - your gene edited cell line may already have been created!

Horizon Cell Lines Catalog

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