Epigenetic Writers, Readers and Erasers

What Is Epigenetics?

Definition: Epigenetics is the study of cellular and physiological traits not caused by changes in the DNA sequence, they may or may not be heritable. They are encoded by covalent modifications of DNA or histones which alters how genes are expressed without altering the DNA sequence

Epigenetics

Epigenetic Markers

The most important epigenetic marks include DNA methylation, histone methylation and histone acetylation. All of which are reversible, i.e. the cell harbours a repertoire of enzymes that add or remove such marks to a specific genomic locus. These enzymes are referred to as epigenetic writers (e.g. DNA methyl transferases or histone acetyl transferases) or epigenetic erasers (e.g. histone demethylases or histone deacetylases).

Epigenetic Mechanisms

Epigenetic marks are read-out by a specific subset of proteins referred to epigenetic readers (e.g. bromodomain-containing genes). Some examples of epigenetic mechanisms include; maternal effects, X-chromosome inactivation and imprinting amongst many others.

Examples of popular knockout cell lines
ARHGEF1CECR2KDM2BSIRT7
ARID1ACREBBPKDM4ASMARCA2
ARID1BDNMT1KDM4DSMARCA4
ARID2DNMT3AKDM4ESMARCC1
ASH1LDNMT3BKDM5CSMARCD1
ASXL2EHMT1KDM6BSMARCD3
ATAD2EHMT2KLF4SP1
ATAD2BEP300L3MBTL2SP100
BAP1EZH1MBD1SP110
BAZ1AH2AFZMBD3SP140
BAZ1BH3F3AMBD4SP3
BAZ2AHDAC1MECP2SUV39H1
BMI1HDAC10MEN1TAF1L
BPTFHDAC11NSD1TET1
BRD1HDAC2PBRM1TET2
BRD2HDAC4PHF6TET3
BRD4HDAC5PHIPTRDMT1
BRD7HDAC7PRMT3TRIM24
BRD8HDAC8RBBP7TRIM66
BRD9HDAC9RING1WHSC1
BRDTHELLSRNF2ZBTB33
BRPF1HIF1ASCFD2ZMYM3
BRPF3JARID2SETDB2ZMYND11
BRWD1JMJD6SIRT1ZMYND8
BRWD3KAT2ASIRT3 
CARM1KAT2BSIRT4 
CBX1KDM1ASIRT5 
CBX5KDM1BSIRT6 

Our cell line range is constantly growing. For our most current list of ready-made cell lines and details of custom made engineering projects you can browse our entire offering via the link below.

Browse Our Cell Line Options


For offline access, many of our popular cell lines that are usually available for immediate delivery are listed in our downloadable our catalog - your gene edited cell line may already have been created!

Horizon Cell Lines Catalog

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