Epigenetics

What Is Epigenetics?

Definition: Epigenetics is the study of cellular and physiological traits not caused by changes in the DNA sequence, they may or may not be heritable. They are encoded by covalent modifications of DNA or histones which alters how genes are expressed without altering the DNA sequence

Epigenetics

Epigenetic Markers

The most important epigenetic marks include DNA methylation, histone methylation and histone acetylation. All of which are reversible, i.e. the cell harbours a repertoire of enzymes that add or remove such marks to a specific genomic locus. These enzymes are referred to as epigenetic writers (e.g. DNA methyl transferases or histone acetyl transferases) or epigenetic erasers (e.g. histone demethylases or histone deacetylases).

Epigenetic Modification

Epigenetic marks are read-out by a specific subset of proteins referred to epigenetic readers (e.g. bromodomain-containing genes). Some examples of epigenetic mechanisms include; maternal effects, X-chromosome inactivation and imprinting amongst many others.

Popular knockout cell lines
ARHGEF1 CECR2 KDM2B SIRT7
ARID1A CREBBP KDM4A SMARCA2
ARID1B DNMT1 KDM4D SMARCA4
ARID2 DNMT3A KDM4E SMARCC1
ASH1L DNMT3B KDM5C SMARCD1
ASXL2 EHMT1 KDM6B SMARCD3
ATAD2 EHMT2 KLF4 SP1
ATAD2B EP300 L3MBTL2 SP100
BAP1 EZH1 MBD1 SP110
BAZ1A H2AFZ MBD3 SP140
BAZ1B H3F3A MBD4 SP3
BAZ2A HDAC1 MECP2 SUV39H1
BMI1 HDAC10 MEN1 TAF1L
BPTF HDAC11 NSD1 TET1
BRD1 HDAC2 PBRM1 TET2
BRD2 HDAC4 PHF6 TET3
BRD4 HDAC5 PHIP TRDMT1
BRD7 HDAC7 PRMT3 TRIM24
BRD8 HDAC8 RBBP7 TRIM66
BRD9 HDAC9 RING1 WHSC1
BRDT HELLS RNF2 ZBTB33
BRPF1 HIF1A SCFD2 ZMYM3
BRPF3 JARID2 SETDB2 ZMYND11
BRWD1 JMJD6 SIRT1 ZMYND8
BRWD3 KAT2A SIRT3  
CARM1 KAT2B SIRT4  
CBX1 KDM1A SIRT5  
CBX5 KDM1B SIRT6  

Our cell line range is constantly growing. For our most current list of ready-made cell lines and details of custom made engineering projects you can browse our entire offering via the link below.

Cell Line Database


For offline access, many of our popular cell lines that are usually available for immediate delivery are listed in our downloadable our catalog - your gene edited cell line may already have been created!

Horizon Cell Lines Catalog

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