This model contains a monoallelic deletion of the Bdnf gene, encoding for the nerve growth factor protein BDNF. Homozygous animals carrying the Bdnf deletion are postnatal lethal. Reductions of BDNF have been observed in patients with Alzheimer's disease (AD), and this model may be useful for understanding the role of BDNF in AD.
- Diet Value
LabDiet #5R24 (RMH2500)
- Age Weight Curve
- Health Report
- Research Application
• Alzheimer's disease
• Memory loss
• Huntington's disease
• Nerve growth and development
• Post-traumatic stress disorder
- Research Area
Schizophrenia and Alzheimer's Disease
• Homozygous knockout rats exhibit complete loss of BDNF protein and have a lifespan of 2-3 days
• Heterozygous Bdnf knockout rats (+/-) display lower total and peripheral activity, suggestive of reduced exploratory behavior
• Heterozygous Bdnf knockout rats (+/-) show decrease in freezing behavior in contextual fear conditioning assay, suggestive of emotional learning and memory deficits
• Background Strain: Sprague-Dawley
- Figure 1
Figure 1: Heterozygous Bdnf knockout rats (+/-) display lower total and peripheral activity compared to wild type
1A. As determined by a baseline locomotor activity test, Bdnf (+/-) rats tend to exhibit lower total activity and a significantly faster rate of habituation to a novel environment, suggestive of reduced exploratory behavior. 1B. Heterozygous Bdnf knockout rats (+/-) show decrease in freezing behavior in a contextual fear conditioning assay, suggestive of emotional learning & memory deficits.
- Figure 2
Figure 2. Homozygous Bdnf knockout rats exhibit complete loss of BDNF protein
Western blot analysis of brain tissue shows a lower level of BDNF in the heterozygous rats and a complete absence of BDNF in homozygous knockout rats (KO=homozygous knockout, Het=heterozygous, WT=wild type).