Bcrp Knockout Rat

TGRS4200

Animal Model
Abcg2

Nomenclature
SD- Abcg2 tm1sage

Zygosity Genotype
Homozygous

Colony Size
Readily Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
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BCRP plays a protective role in neurotoxicity by limiting the efflux of xenobiotics into the brain. Homozygous null rats demonstrate increased exposure in the brain and plasma when dosed with BCRP-specific substrates.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• DMPKEfflux assay
• Neurotoxicology
• Formulation Blood brain barrier efflux
• Drug-drug interactions
• Tissue distribution
• Efficacy assay
Research Area
Efflux Transporters

Characteristics

Characteristics
• Biallelic 588 bp deletion within Abcg2 gene
• Homozygous knockouts display total loss of protein via Western blot
• Increased oral bioavailability of BCRP-specific substrates
Background Strain: Sprague-Dawley
Figure 1
Bcrp Knockout Rat - Figure 1
Figure 1: Dantrolene level of Bcrp (-/-) and wild type rats 2 hours after treatment (nM/g)
Figure 2
Bcrp Knockout Rat - Figure 2
Figure 2: Oral absorption of sulfasalazine
Protocols & Documents
Additional Information

Additional Information

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