Interested in a complete study? Horizon now offers our In Vivo Drug Transporter Assay service. BCRP plays a protective role in neurotoxicity by limiting the efflux of xenobiotics into the brain. Homozygous null rats demonstrate increased exposure in the brain and plasma when dosed with BCRP-specific substrates.
• Biallelic 588 bp deletion within Abcg2 gene • Homozygous knockouts display total loss of protein via Western blot • Increased oral bioavailability of BCRP-specific substrates • Background Strain: Sprague-Dawley
Figure 1: Dantrolene level of Bcrp (-/-) and wild type rats 2 hours after treatment (nM/g)