Alpha-Synuclein SNCA Knockout Rat


Animal Model
Alpha Synuclein KO

SD- KO-Alpha-Synucleintm1sage

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Technical Information
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the endogenous rat SNCA gene, encoding the alpha-synuclein protein. This model was generated using the CRISPR/Cas9 genome targeting strategy. Mutations and multiplications of the SNCA gene have been linked to early-onset Parkinson’s disease (PD), making this model useful for understanding alpha-synuclein biology and PD pathogenesis.

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Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Health Report
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Research Applications

Research Application
• Parkinson's disease
• Dopaminergic cell toxicity
Research Area
Parkinson's Disease


• Background Strain: Sprague Dawley
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