Alpha-Synuclein SNCA Knockout Rat

TGRL10150

Animal Model
Alpha Synuclein KO

Nomenclature
SD- KO-Alpha-Synucleintm1sage

Zygosity Genotype
Homozygous

Colony Size
Available

Name and Catalog ID
Qty
Unit Price
$320.00

Commercial pricing applied

The price provided is for the animal model only. Shipping containers and Hydrogel packs will be calculated based on the number and age of animals following completion of the order. Please Contact Us for more information on the price of these items.

Availability: In stock

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Technical Information
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the endogenous rat SNCA gene, encoding the alpha-synuclein protein. This model was generated using the CRISPR/Cas9 genome targeting strategy. Mutations and multiplications of the SNCA gene have been linked to early-onset Parkinson’s disease (PD), making this model useful for understanding alpha-synuclein biology and PD pathogenesis.

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Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Health Report
PDF Download

Research Applications

Research Application
• Parkinson's disease
• Dopaminergic cell toxicity
Research Area
Parkinson's Disease

Characteristics

Characteristics
• Background Strain: Sprague Dawley
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