Alpha-Synuclein A53T SNCA Knock-in Rat


Animal Model
Alpha-Synuclein A53T KI

SD- Alpha-Synuclein KI A53T tm1sage

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Technical Information
Developed in collaboration with The Michael J. Fox Foundation, this model contains a knockin of the A53T-mutated SNCA gene deeming the rat SNCA gene non-functional. The knockin contains humanized amino acids for the region spanning amino acids 53-122. The resulting model expresses a humanized A53T alpha-synuclein protein without endogenous rat alpha-synuclein. This model was generated using CRISPR/Cas9 genome targeting strategies. The A53T mutation in the SNCA gene has been linked to early-onset Parkinson’s disease (PD), making this model useful for understanding alpha-synuclein biology and PD pathogenesis.

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Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Health Report
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Research Applications

Research Application
• Parkinson's disease
• Dopaminergic cell toxicity
Research Area
Parkinson's Disease


• Background Strain: Sprague Dawley
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