Trpv1 Knockout Rat

TGRS5530

Animal Model
Trpv1

Nomenclature
SD- Trpv1 tm1sage

Zygosity Genotype
Heterozygous

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
This model contains a biallelic deletion of the Trpv1 gene, encoding for the transient receptor potential cation channel subfamily V member 1. Capsaicin, the component in chili peppers that makes them hot, is an exogenous ligand for Trpv1. Trpv1 is also activated by heat.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Pain
• Nociception
• Analgesia
• Thermoregulation
• Cannabinoids
Research Area
Pain

Characteristics

Characteristics
• Homozygous knockout rats exhibit complete loss of Trpv1 protein
• Trpv1 knockout rats show hyposensitivity to thermal pain via hot plate assay
Background Strain: Sprague-Dawley
Figure 1
Trpv1 Knockout Rat - Figure 1
Figure 1: Western blot demonstrating lack of TRPV1 in TRPV1 knockout rats.
Brain homogenates were probed with anti-rat TRPV1 ACC-029 (Alamone Labs) at 1:200.
Figure 2
Trpv1 Knockout Rat - Figure 2
Figure 2: Thermal insensitivity in TRPV1 knockout rats.
TRPV1 knockout rats show increased foot licking latency in the hot plate test.
*** = p < 0.001.
Protocols & Documents
Additional Information

Additional Information

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