ROS1 Translocation IHC Reference Standard [DISCONTINUED]

ROS; MCF3; c-ros-1

Format Type
Biomarker Specific

FFPE Block


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The ROS1 Translocation IHC Reference Standard is a highly-characterized quality control material which contains precisely defined positive and negative protein expressing cell lines on the same slide. The ROS1 Reference Standard can be utilized during assay development, for optimization, validation of your Laboratory Developed Test (LDT) and verification of a commercial IHC assay. FFPE block format allows for authentic in-process control from sectioning to reporting.


Availability: Discontinued

Bulk order discount
Technical Information
The availability of precisely defined reference materials offers an industry standard for development and quality control of IHC assays, improving the accuracy and reproducibility. IHC HDx Reference Standards provide laboratories with a consistent source of positive and negative reference material on one slide.

• Precisely defined positive and negative ROS1 protein expressing cell lines on the same slide.
• Cost effective for routine adoption.
• Up to 500 sections (3-5µm) available from a 0.5cm block.
• Cell lines verified by IHC assay and Quantitative Digital Pathology (QDP).

• Place your sample alongside HDx Reference Standards to provide confidence through verification and validation activities.
• Guide the evaluation of antibodies based on their sensitivity and specificity.
• Gain additional confidence when optimizing and monitoring the performance of your assay through application of a consistent reference standard.

Technical Data

Protein expression is confirmed using a biomarker specific IHC assay to ensure the quality of our IHC Reference Standard.
Mutation Type
Fixation Method
10% Formalin
Core Diameter
Cell Density
1-1.5 x 104 cells/core dependent on cell size

Product Information

Intended Use
For routine performance monitoring (Research Use Only)
Unit Size
One 0.5cm FFPE Block

General Information

24 months


Core 1
Core 2
Core Legends
Typical Staining Pattern of ROS1 Translocation

Core 1: No cytoplasmic, granular staining pattern observed in the negative cell line core
Core 2: Strong cytoplasmic granular staining pattern observed in the positive cell line core

(Cell Signalling, D4D6, #3287 on the automated Leica BOND Max stainer)
Protocols & Documents

Please browse our collection of downloads below.

If you need any support, advice or additional documentation then don't hesitate to contact us here.

Certificate of Analysis

Batch ID: 19218
PDF Download

Documents & Related Literature

Safety Data Sheet
PDF Download
Order & Delivery Information

Please see our terms and conditions of ordering.

If you need any support, advice or additional documentation then don't hesitate to contact us here.

Order Information

We accept orders using the following methods:


Our online catalog and ordering system can be used to search our full menu of available HDx™ Reference Standards. Select your desired reference standards and add them to the shopping basket. Your order can be submitted instantly using credit card, telephone ordering or a purchase order number as the preferred payment method.


If you prefer to send us orders outside our online ordering system, please see the Contact Us page for telephone, fax, and email details in order to place an order.  We recommend that you use our online system to identify the products you require and their respective “HD” product codes. To order offline we will require the following information:

  • Product code(s) of the item(s) you wish to order (e.g. "HD123")
  • Your name, email address, title and organization
  • Shipping address and billing address with contact names
  • Purchase Order number if you have one
  • Telephone number
  • VAT Number (European Countries only)

Shipping Information

Shipping information for all territories can be found on our Shipping Charges page. This includes Shipping and Handling fees, as well as shipping conditions for each product range.

If you’re having trouble ordering or finding what you’re looking for, or if you require something we don’t yet offer, please see below for more information: 

Contact Us Terms of Ordering


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