CRISPR-created Animal Models: The Technical Lowdown



Category: In Vivo Models

27/09/2018

FREE Webinar hosted by The Scientist.

Creating reproducible animal models for long-term studies can often be problematic due to the complexity of the genetic modification(s) required. Suboptimal design strategies compound the challenges by generating undesired genotypic or phenotypic results. CRISPR-Cas9 or zinc-finger nuclease (ZFN)-based technologies can circumvent the challenges of complex genetic alterations due to the precision inherent to these methods.

Beyond these methods, which result in constitutive changes to the genome, other genome editing methods are available; these include humanization, conditional knockout, point mutation, and reporter tagging. The sponsor of this webinar, Horizon Discovery, offers custom in vivo model generation services. Join us to learn how to go from concept to F1 in five months.

Topics covered: A technical overview of custom animal models created with CRISPR Custom animal models case studies.

Speaker: Dr. Jochen Hartner is a Field Application Leader for In-vivo Services and Products at Horizon Discovery. Before joining Horizon in 2016, he headed the Scientific Project Management of Custom Transgenic Animal Model Generation at Taconic Biosciences. During his postdoctoral training with Dr. Stuart H. Orkin at the Dana-Farber Cancer Institute, Dr. Hartner studied the physiological roles of posttranscriptional gene regulation by RNA editing and microRNA in the hematopoietic system. In his doctoral work with Dr. Peter H. Seeburg at the Max-Planck Institute for Medical Research, Dr. Hartner investigated the in-vivo roles of RNA editing enzymes in the mouse brain and embryo.

View details about our Custom Model Generation service

 
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