Chalice Bioinformatics Software

Developed to provide collaborators the same proven analysis tools employed by Horizon’s combination screening scientists, Chalice is a proprietary data analysis platform for characterizing single agent and multi-target screening results.  The tool allows researchers to quantitatively assess the strength of combination interactions and to extract valuable insights, discoveries, and data trends from high-throughput combination activity profiling experiments.

  • Dose response, doubling time, IC50, GI50, maximum response and more
  • Multiple synergy models to choose from for data analysis
  • Results can be organized according to user preferences including organizing by test substance or mechanism, cell line, genetic or mutational information
  • Custom algorithms can be easily included for data analysis

Try the Trial Version Chalice online

Contact us to get access to the Full Chalice Software 


Chalice is available in three formats:

Chalice Enterprise, for the Whole Organization

  • Centralized analysis server
  • Consistent combination interpretation
  • Institutionalized knowledge

Chalice Desktop, for the Individual Scientist

  • Keep your data on your desktop
  • Full combination analysis features

Chalice Web Results

  • Online Combination Analysis via our convenient web interface
  • Submit your blinded data online
  • Receive a Synergy report by email

Features Versus Version

 Web ResultsDesktopEnterprise

Combination Analysis




Synergy Score


Dose Response Matrix Surface Visualization


Loewe Addivity Model and Excess Surface Visualization




Combination Index, Bliss Interaction, Highest Single Agent and 5+ Additional Combination Models



Global Combination Screen Matrix View



Dose Matrix Concentration Limiting







Single Agent Analysis




Single Agent Dose Response Curve Fit Model


Additional Single Agent Curve Models



IC50, EC50, GI50, Doubling Time & Additional Attributes







Data Management










Filtering/ Sorting








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System Requirements




Data Storage



Oracle Server

Number of Seats




Access Chalice user manual online or Download as a PDF

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