Chalice Bioinformatics Software

Developed to provide collaborators the same proven analysis tools employed by Horizon’s combination screening scientists, Chalice is a proprietary data analysis platform for characterizing single agent and multi-target screening results.  The tool allows researchers to quantitatively assess the strength of combination interactions and to extract valuable insights, discoveries, and data trends from high-throughput combination activity profiling experiments.

  • Dose response, doubling time, IC50, GI50, maximum response and more
  • Multiple synergy models to choose from for data analysis
  • Results can be organized according to user preferences including organizing by test substance or mechanism, cell line, genetic or mutational information
  • Custom algorithms can be easily included for data analysis

Try the Trial Version Chalice online

Contact us to get access to the Full Chalice Software 

 

Chalice is available in three formats:

Chalice Enterprise, for the Whole Organization

  • Centralized analysis server
  • Consistent combination interpretation
  • Institutionalized knowledge

Chalice Desktop, for the Individual Scientist

  • Keep your data on your desktop
  • Full combination analysis features

Chalice Web Results

  • Online Combination Analysis via our convenient web interface
  • Submit your blinded data online
  • Receive a Synergy report by email

Features Versus Version

 Web ResultsDesktopEnterprise

Combination Analysis

 

 

 

Synergy Score

   

Dose Response Matrix Surface Visualization

     

Loewe Addivity Model and Excess Surface Visualization

     

Isobologram

     

Combination Index, Bliss Interaction, Highest Single Agent and 5+ Additional Combination Models

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Global Combination Screen Matrix View

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Dose Matrix Concentration Limiting

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Single Agent Analysis

 

 

 

Single Agent Dose Response Curve Fit Model

     

Additional Single Agent Curve Models

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IC50, EC50, GI50, Doubling Time & Additional Attributes

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Data Management

 

 

 

Import/Export

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Collections

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Filtering/ Sorting

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Reporting

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Blinding

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  ✔   ✔

 

 

 

 

System Requirements

 

 

 

Data Storage

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Desktop

Oracle Server

Number of Seats

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Single

Multiple

Access Chalice user manual online or Download as a PDF

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