Although CRISPR knockout screening has provided a powerful and precise solution to identify and validate novel drug targets, and to elucidate unknown drug mechanisms, there are some biological studies for which CRISPR knockout screens are not applicable. CRISPRa (and CRISPRi) screening opens up many new possibilities.
What is CRISPRa?
CRISPR Activation (CRISPRa) screening provides the capacity to study gain of gene function which allows us to broaden the range of possible applications. They can power our customers’ discovery and drug development programs by offering the highest quality and highest confidence in their screening results
In combination with CRISPRi, our CRISPRa screen can reveal ‘switch’ like genes that display opposing effects when activated or inhibited in the presence of the drug of interest, bringing the prospect of unambiguous target discovery closer.