OncoReference Data Set

Activity profiles of oncology focused standard-of-care drugs, emerging therapeutics, and molecular probes across hundreds of cell lines

OncoReference allows you to easily access single agent activity profiles of 200 oncology focused compounds screened across a panel of hundreds of cancer cell lines from 20 different indications. Compare the activity of your molecules to standard-of-care drugs and emerging therapeutics.

Compounds cover a wide range of mechanistic classes including apoptosis inducers, kinase inhibitors, DNA damage inducers and chromatin modulators.

OncoReference Data Set includes

  • Activity Profiles: Single agent activity profiles of 200 oncology focused compounds
  • Cell Lines: Hundreds of clinically relevant cancer cell lines from 20 indications
  • Dose Response Format: 10-point, 3-fold dilution series
  • Treatment Time: 72 hours
  • Readout: Growth Inhibition and Inhibition as measured by cell proliferation (ATP endpoint). Growth Inhibition readout allows for differentiation of cytostatic and cytotoxic response of compounds
You will receive
  • Dose response curves
  • IC50, GI50, EC50
  • Maximum response and more
  • Access to Chalice™  Viewer bioinformatics software 
  • In-depth tutorial of software and data analysis approaches

 

Compounds includeCell Lines Collection
  • Apoptosis Inducers
  • PI3K/mTOR/Akt Inhibitors
  • Proteosome Inhibitors
  • DNA Damage Response Proteins
  • DNA Damage Inducers
  • Cell Cycle Inhibitors
  • Cytoskeletal Inhibitors
  • MAP Kinase Family Inhibitors
  • Protein Tyrosine Kinase Inhibitors
  • Chromatin Modulators
  • And more…

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