RNA Fusion Reference Standards

Ensure that your results are accurate when setting up targeted NGS, RTPCR or RT-qPCR fusion detection assays

Lead the way with reliable, consistent and defined RNA Reference Standards. The ALK-RET-ROS1 targeted FFPE RNA Fusion Reference Standards are a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS, RT-PCR and RT-qPCR assays aimed at detecting gene fusions. Each section contains formalin-fixed, paraffin-embedded (FFPE) cell line multiplex verified to contain EML4-ALK (Variant 1), CCDC6-RET and SLC34A2-ROS1 fusions.

  • Targeted EML4-ALK, CCDC6-RET and SLC34A2-ROS1 verified cell line multiplex in an FFPE format
  • Evaluate your workflow integrity from pre-analytical RNA extraction through to fusion detection
  • Optimize and validate new targeted RNA panels and routinely monitor the performance of your assay

RNA Reference Material Specifications

HD784 Reference Standard:
FusionsFormatThicknessMinimum RNA yield/section
Postive for:
EML4-ALK (Variant 1)
CCDC6-RET
SLC34A2-ROS1
1 FFPE section 10µm > 100 ng
ALK-RET-ROS1 Fusion FFPE RNA Application Note
HD783 Reference Standard:
FusionsFormatThicknessMinimum RNA yield/section
Negative for:
EML4-ALK (Variant 1)
CCDC6-RET
SLC34A2-ROS1
1 FFPE section 10µm > 100 ng
ALK-RET-ROS1 Fusion Negative FFPE RNA

Independent Controls

Produced outside of your laboratory, the Reference Standards are manufactured under ISO9001 to ensure their reproducibility and reliability. As the cell lines are either engineered or clonally derived from a fusion background, they provide a renewable source of reference material allowing for a reproducible and consistent external quality control.

Analytical Standard

Reference Standards can be applied to assess analytical variability and reproducibility between platforms, laboratories, operators and assays. Achieve further confidence in your clinical workflow, from extraction to analysis with a defined analytical standard.

Compatible with a broad range of fusion detecting panels

  EML4-ALK CCDC6-RET SLC34A2-ROS1
Archer™ FusionPlex Panels
FusionPlex Oncology Reaserch Panels
FusionPlex Lung Thyroid Panel
FusionPlex CTL Panel
FusionPlex Solid Tumor Panel
FusionPlex ALK, RET, ROS1 Panel v2
FusionPlex Heme Panel N/A*
FusionPlex Sarcoma Panel N/A*
NuGEN™
Ovation Fusion Panel Target Enrichment System v2
ThermoFisher Scientific
Oncomine™ Focus Assay
Oncomine™ solid tumor fusion transcript kit
NanoString Technologies
nCounter®

*Archer Heme and Sarcoma panels do not target RET fusions

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