This model contains a biallelic deletion of the neuroligin 3 gene (Nlgn3). Mutations in Nlgn3 have been linked with autism and Asperger's syndrome. This model is useful for understanding the role of neuroligins in the development of autism spectrum disorders.
• This model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization by Dr. Richard Paylor at Baylor College of Medicine • Preliminary results suggest that Nlgn3 knockout rats are less anxious and exhibit decreased juvenile play, deficits in sensorimotor gating and increased perseverative behaviors • Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot • Mutations in Nlgn3 have been associated with autism and Asperger's syndrome • Nlgn3 is a member of the broader neuroligins, neuronal cell surface proteins thought to play a role in synaptic plasticity • Background Strain: Sprague-Dawley
Figure 1: Loss of neuroligin 3 protein in Nlgn3 knockout rats Neuroligin 3 protein expression is disrupted in Nlgn3 knockout rats as compared to wild type controls as demonstrated by Western blot. Actin staining demonstrates equal sample loading.