Neuroligin 3 (Nlgn3) Knockout Rat


Animal Model

SD- Nlgn3 tm1sage

Zygosity Genotype

Colony Size


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Technical Information
This model contains a biallelic deletion of the neuroligin 3 gene (Nlgn3). Mutations in Nlgn3 have been linked with autism and Asperger's syndrome. This model is useful for understanding the role of neuroligins in the development of autism spectrum disorders.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Autism
• Asperger's syndrome
• Synaptic plasticity
Research Area


• This model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization by Dr. Richard Paylor at Baylor College of Medicine
• Preliminary results suggest that Nlgn3 knockout rats are less anxious and exhibit decreased juvenile play, deficits in sensorimotor gating and increased perseverative behaviors
• Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
• Mutations in Nlgn3 have been associated with autism and Asperger's syndrome
• Nlgn3 is a member of the broader neuroligins, neuronal cell surface proteins thought to play a role in synaptic plasticity
Background Strain: Sprague-Dawley
Figure 1
Neuroligin 3 (Nlgn3) Knockout Rat - Figure 1
Figure 1: Loss of neuroligin 3 protein in Nlgn3 knockout rats
Neuroligin 3 protein expression is disrupted in Nlgn3 knockout rats as compared to wild type controls as demonstrated by Western blot. Actin staining demonstrates equal sample loading.
Protocols & Documents
Additional Information

Additional Information


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