Mrp1 Knockout Rat

TGRS4270

Animal Model
Abcc1a

Nomenclature
SD- Abcc1a tm1sage

Zygosity Genotype
Cryopreserved as heterozygous embryos

Colony Size
Limited Availability

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
This model contains a 43 base pair bi-allelic deletion within the Mrp1 gene, synonym Abcc1a (ATP-binding cassette, sub-family C [CFTR/MRP], member 1a), encoding an ATP-dependent drug transporter.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Health Report
PDF Download

Research Applications

Research Application
• Drug transport
• Drug resistance studies
• Studying excretion pathways in cancer
Research Area
Efflux Transporters

Characteristics

Characteristics
• Homozygous knockouts display total loss of protein via Western blot
• Decreased transport of glutatione-conjugated substrates
• Increased bioavailability of specific substrate Fluorescein
Background Strain: Sprague-Dawley
Figure 1
Mrp1 Knockout Rat - Figure 1
Figure 1: Western blot using tissue isolated from both wild type and Mrp1 homozygous knockout rats.
Additional Information

Additional Information

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