A client came to us with a project they were struggling to generate using ES Cells. This group had been working on generating the model for three years with unsuccessful results. Due to the ability of ZFNs to modify single-cell embryos, we felt confident we could generate the model and transmit the mutation through the germline.
A client came to us with a need for a more translational model for predicting human response of their candidate drug. Mouse models exist for their area of study, but do not display the desired disease phenotype of drug response.