Primary Rat Hepatocytes
Analyze the drug metabolism of your compounds with confidence using Horizon’s PXR, CAR, Double Knockout and wild-type (WT) SD Rat Hepatocytes.
- Pre-screened for plateability
- Characterized for metabolic activity, CYP induction, and transporter efflux activity
- Cryopreserved, maximized re-thaw viability (~90%), recovery, and plating efficiency
- Available from single or multiple donors
Please view details of these Rat Hepatocytes that are available through our partnership with In Vitro ADMET Labroatories, Inc:
| Gene Knockout | Horizon Rat Model # | IVAL Catalog # | Product Characterization Sheet # | Tested for Drug Metabolism Activity |
|---|---|---|---|---|
| Bcrp | TGRS4200 | 82118 | RS129 | ECOD, UGT, Sulfotransferase |
| CAR | TGRS8190 | 82114 | RS132 | ECOD, UGT, Sulfotransferase, PCN and TCPOBOP Treated |
| Mdr1a | TGRS3570 | 82126 | RS131 | ECOD, UGT, Sulfotransferase |
| Mdr1a/b | TGRS7070 | 82122 | RS130 | ECOD, UGT, Sulfotransferase |
| PXR | TGRS4130 | 82169 | RS133 | ECOD, UGT, Sulfotransferase, PCN and TCPOBOP Treated |
| PXR/CAR | TGRS9100 | 82165 | RS134 | ECOD, UGT, Sulfotransferase, PCN and TCPOBOP Treated |
| WT SD Rat Hepatocytes | N/A | 82018 | RSM111 | ECOD, UGT, Sulfotransferase |