Autism

The autism spectrum disorders are characterized by deficits in social behavior, language, cognition, and the presence of stereotyped and repeated behaviors and interests. Symptoms appear early in childhood and are usually diagnosed by the age of three. The autism spectrum disorders comprise a number of developmental disorders, including Asperger’s syndrome and Rett syndrome. Related developmental disorders include Fragile X syndrome and Timothy syndrome.

Genetic Links: NRXN1, NLGN3, PTEN and FMR1

The underlying cause of autism spectrum disorders remains unknown, however recent studies have suggested a genetic basis. Mutations in the genes neurexin 1 (Nrxn1), neuroligin 3 (Nlgn3), and phosphatase and tensin homolog (Pten) have all been linked to autism. Mutations in methyl-CpG-binding protein (MECP2) result in Rett syndrome. An expansion of CGG trinucleotide repeat in Fragile X mental retardation1 (Fmr1) has been implicated in Fragile X syndrome.

To further the understanding of the autism spectrum disorders, Horizon has created a range of autism animal models, the first targeted knockout rats for the genes Nlgn3, Fmr1, Nrxn1, Pten, mGluR5, MeCP2, Cntnap2 and MET.

Request more information

Animal Models of Autism

Animal models of Autism Spectrum Disorders:
NIgn3 Knockout Fmr1 Knockout Nrxn1 Knockout
Pten Knockout mGluR5 Knockout MeCP2 Knockout
Cntnap2 Knockout MET Knockout  

Download our brochure for a full list of available research animal models.

Knockout Rat Models for Autism

ASD Model Publications

  • Quantitative positron emission tomography of mGluR5 in rat brain with [18F]PSS232 at minimal invasiveness and reduced model complexity
  • Phenotypic Characterization of Nonsocial Behavioral Impairment in Neurexin 1α Knockout Rats.
  • Behavioural methods used in rodent models of autism spectrum disorders: Current standards and new developments
  • Degraded speech sound processing in a rat model of fragile X syndrome
  • Fmr1 and Nlgn3 knockout rats: Novel tools for investigating autism spectrum disorders
Back to top