Vgat-Cre Rat

TGRL9310

Animal Model
Vgat-Cre, slc32A1-cre

Nomenclature
LEH-Vgat-Cretm1sage

Zygosity Genotype
Homozygous

Colony Size
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Availability: In stock

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Technical Information
This model expresses cre-recombinase under the control of the endogenous solute carrier family 32 member 1 (Vgat) promoter enabling specific expression in Vgat positive GABAergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of the Vgat gene. The Vgat-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines.
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Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Health Report
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Research Applications

Research Application
• Optogenetics
• Expression/knockout of floxed genes
Research Area
Optogenetics Rats

Characteristics

Characteristics
• Cre recombinase driven by endogenous Vgat promoter
• No observed ectopic expression of cre
• Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC
Background Strain: Long Evans Hooded
Figure 1
Vgat-Cre Rat - Figure 1
Figure 1. A combination of Slc32A1 (Vgat) in situ hybridization and Tdtomato antibody staining confirms that the Cre recombinase is expressed in the Slc32A1 (Vgat) positive neurons in the brain.
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