BSEP Knockout Rat

TGRS8050

Animal Model
Abcb11

Nomenclature
SD- Abcb11 tm1sage

Zygosity Genotype
Heterozygous

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
Abcb11 encodes the bile salt export pump (BSEP) found in the liver. BSEP is critical in the secretion of bile by releasing bile salts from the liver, and mutations in BSEP have been associated with progressive familial intrahepatic cholestasis in humans.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
PDF Download

Research Applications

Research Application
• Cholestasis
• Drug-induced cholestasis (DIC)
• Transporter assays
• Drug-drug interactions
Research Area
Efflux Transporters

Characteristics

Characteristics
• Biallelic 8bp deletion within the Abcb11 gene
• Homozygous Knockouts exhibit complete loss of protein via Western blot
Background Strain: Sprague-Dawley
Figure 1
BSEP Knockout Rat - Figure 1
Figure 1: Western blot using tissue isolated from both wild type and BSEP homozygous knockout rats.
Protocols & Documents
Additional Information

Additional Information

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