ApoE Knockout Rat

TGRA3710

Animal Model
ApoE

Nomenclature
SD- ApoE tm1sage

Zygosity Genotype
Homozygous

Colony Size
Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ApoE result in disrupted transportation of lipoproteins, fat-soluble vitamins and cholesterol into the lymph systems, and then into blood.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
PDF Download

Research Applications

Research Application
• Alzheimer's disease
• Neurodegenerative diseases
Research Area
Alzheimer's Disease

Characteristics

Characteristics
• 16 bp deletion within Exon 3 on chromosome 1
• Homozygous knockouts exhibit complete loss of ApoE protein via Western blot
• At an early age (5- and 10-week-old), ApoE knockouts demonstrate significantly higher serum cholesterol
• Administration of high fat diets to ApoE KO rats has resulted in significantly reduced lifespan.
• Horizon Discovery does not recommend administering high fat diets to ApoE KO rats.
Background Strain: Sprague-Dawley
Figure 1
ApoE Knockout Rat - Figure 1
Figure 1: 5- and 10-week-old ApoE knockout rats display increased serum cholesterol levels as compared to wild type animals
ApoE (-/-) rats have higher total cholesterol levels at 5- and 10-weeks of age with normal diet.
Additional Information

Additional Information

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