Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ApoE result in disrupted transportation of lipoproteins, fat-soluble vitamins and cholesterol into the lymph systems, and then into blood.
- Diet Value
LabDiet #5R24 (RMH2500)
- Age Weight Curve
- Health Report
- Research Application
• Alzheimer's disease
• Neurodegenerative diseases
- Research Area
• 16 bp deletion within Exon 3 on chromosome 1
• Homozygous knockouts exhibit complete loss of ApoE protein via Western blot
• At an early age (5- and 10-week-old), ApoE knockouts demonstrate significantly higher serum cholesterol
• Administration of high fat diets to ApoE KO rats has resulted in significantly reduced lifespan.
• Horizon Discovery does not recommend administering high fat diets to ApoE KO rats.
• Background Strain: Sprague-Dawley
- Figure 1
Figure 1: 5- and 10-week-old ApoE knockout rats display increased serum cholesterol levels as compared to wild type animals
ApoE (-/-) rats have higher total cholesterol levels at 5- and 10-weeks of age with normal diet.