ring finger and CHY zinc finger domain containing 1
Alias
ARNIP | CHIMP | PIRH2 | PRO1996 | RNF199 | ZCHY | ZNF363
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013].