Human MAPT (V337M/V337M) iPSC-derived Neural Stem Cells

Synonyms
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103

ax0322
$1,280.00

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Technical Information
Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the V337M mutation (GTG>ATG) in the MAPT gene. This line is homozygous for the V337M mutation so both alleles contain the mutation. Click on the product images to see the data and further details. The V337M mutation in MAPT has been implicated in frontotemporal dementia and may have a role in Alzheimer's disease. The mutation leads to accelerated aggregation of MAPT/tau protein into filament structures (Nacharaju et al., 1999) and makes the MAPT/tau protein more susceptible to hyperphosphorylation (Alonso et al., 2004).

Technical Data

Genotype
MAPT (V337M/V337M)
Functional Area
Neurodegenerative Disease
Genetic Modification
GGG > GGA
Gene Copy Number
MAPT: 1.88
SNP Frequency %
V337M: 99.72%
Karyotype
Normal

General Information

Growth Properties
Adherent
Cell Number
1.5 x 106
Freeze Medium
Neural Expansion Medium (ax0030-500) with 10% DMSO
Method of Reprogramming
Episomal
Gene Editing Modification
Contains a puromycin resistance cassette (intronic)

Donor Information

Gender
Female
Age
64 years old
Ethnicity
Caucasian

Cell Culture

Biosafety Level
Biosafety Level 1
Cell Culture Image
Human MAPT (V337M/V337M) iPSC-derived Neural Stem Cells - Cell Culture Image
DNA sequencing of Human MAPT (V337M/V337M) iPSCs shows that both alleles contain the V337M mutation (GTG > ATG) at the locus. A silent mutation (underlined red) is introduced to prevent re-cutting of the gene edited region. This does not affect the amino acid sequence of the protein.
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$200

 

 

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$130

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£85.00

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$340

  

 

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