Human LRRK2 (G2019S/+) iPSC-derived Neural Stem Cells



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Technical Information
Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is heterozygous for the G2019S mutation where one allele contains the mutation and the other allele is wild type at the locus. Click on the product images to see the data and further details. The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).

Technical Data

LRRK2 (G2019S/+)
Functional Area
Neurodegenerative Disease
Genetic Modification
Gene Copy Number
LRKK2: 1.80
SNP Frequency %
G2019S: 48.90%

General Information

Growth Properties
Cell Number
1.5 x 106
Freeze Medium
Neural Expansion Medium (ax0030-500) with 10% DMSO
Method of Reprogramming
Gene Editing Modification
Contains a puromycin resistance cassette (intronic)

Donor Information

64 years old

Cell Culture

Biosafety Level
Biosafety Level 1
Cell Culture Image
Human LRRK2 (G2019S/+) iPSC-derived Neural Stem Cells - Cell Culture Image

Expression of neural stem cell marker Nestin (red) and LRRK2 protein (green) in Human LRRK2 (G2019S/+) iPSC-derived Neural Stem Cells

Human LRRK2 (G2019S/+) iPSC-derived Neural Stem Cells - Cell Culture Image

DNA sequencing of Human LRRK2 (G2019S/+) iPSCs shows that one allele contains the G2019S mutation (GGC > AGC) and the other is wildtype at the locus. A silent mutation (underlined red) is introduced to prevent re-cutting of the gene edited region. This does not affect the amino acid sequence of the protein.

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