Human LRRK2 (G2019S/G2019S) iPSC-derived Neural Stem Cells



Availability: In stock

Dispatched within 5 working days

Bulk order discount
Technical Information
Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the R406W mutation (CGG>TGG) into the MAPT gene. This line is homozygous for the R406W mutation so both alleles contain the mutation. Click on the product images to see the data and further details. The R406W mutation in MAPT has been implicated in familial frontotemporal dementia and parkinsonism (Hutton et al., 1998; Behnam et al., 2015) and has been seen in patients with clinical presentation resembling Alzheimer's disease (Rademakers et al., 2003; Lindquist et al., 2008). The R406W mutation reduces the ability of MAPT/tau to bind to microtubules in vitro (Hong et al., 1998).

Technical Data

LRRK2 (G2019S/G2019S)
Functional Area
Neurodegenerative Disease
Genetic Modification
Gene Copy Number
LRRK2: 1.87
SNP Frequency %
G2019S: 99.93%

General Information

Growth Properties
Cell Number
1.5 x 106
Freeze Medium
Neural Expansion Medium (ax0030-500) with 10% DMSO
Method of Reprogramming
Gene Editing Modification
Contains a puromycin resistance cassette (intronic)

Donor Information

64 years old

Cell Culture

Biosafety Level
Biosafety Level 1
Cell Culture Image
Human LRRK2 (G2019S/G2019S) iPSC-derived Neural Stem Cells - Cell Culture Image

Expression of neural stem cell marker Nestin (red) and LRRK2 protein (green) in Human LRRK2 (G2019S/G2019S) iPSC-derived Neural Stem Cells

Human LRRK2 (G2019S/G2019S) iPSC-derived Neural Stem Cells - Cell Culture Image

DNA sequencing of Human LRRK2 (G2019S/G2019S) iPSCs shows that both alleles contain the G2019S mutation (GGC > AGC) at the locus. A silent mutation (underlined red) is introduced to prevent re-cutting of the gene edited region. This does not affect the amino acid sequence of the protein.

Order & Delivery Information

Please see our terms and conditions of ordering.

If you need any support, advice or additional documentation then don't hesitate to contact us here.

Order Information

We accept orders using the following methods:


Our online catalog and ordering system can be used to search our full menu of available Cell Lines. Select your desired products and add them to the shopping basket. Your order can be submitted instantly using credit card, telephone ordering or a purchase order number as the preferred payment method.


If you prefer to send us orders outside our online ordering system, please see the Contact Us page for telephone, fax, and email details in order to place an order.  We recommend that you use our online system to identify the products you require and their respective product codes. To order offline we will require the following information:

  • Product code(s) of the item(s) you wish to order (e.g. "HD123")
  • Your name, email address, title and organization
  • Shipping address and billing address with contact names
  • Purchase Order number if you have one
  • Telephone number
  • VAT Number (European Countries only)

Shipping Information

We aim to ship your order direct within 5 business days of receipt of your order and we will notify you of your expected delivery date. We ship direct to the following territories:

TerritoryPrice (USD)Price (EUR)
Price (GBP)Service

US & Canada




FEDEX International Priority

EU Countries
(Excluding Italy)




FEDEX International Priority

Rest of the World
(Excluding Japan, Israel, Hong Kong) 




FEDEX International Priority

It is possible to use your own FEDEX account for shipment of goods and we will apply a small fee ($5.00 / £5.00 / €5.00) to cover packaging costs.

If you’re having trouble ordering or finding what you’re looking for, or if you require something we don’t yet offer, please see below for more information: 

Contact Us Terms of Ordering


Write Your Own Review

You're reviewing: Human LRRK2 (G2019S/G2019S) iPSC-derived Neural Stem Cells

How do you rate this product? *

1 1 star
2 2 star
3 3 star
4 4 star
5 5 star
Back to top