epithelial cell adhesion molecule
Alias
DIAR5 | EGP-2 | EGP314 | EGP40 | ESA | HNPCC8 | KS1/4 | KSA | M4S1 | MIC18 | MK-1 | TACSTD1 | TROP1
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008].