Cancer-related cell lines

Choose from over 300 knock-in and knockout cell line models in many standard cancer cell lines such as DLD1, MCF10A, and HCT116.

BBC3 ( Human )

Entrez Gene 27113 entrezgene 27113
Search another gene
BCL2 binding component 3

Alias

JFY-1 | JFY1 | PUMA

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].

Recapitulate disease phenotypes

Endogenous knock-in cell lines enable a clear understanding of a gene or mutation’s contribution to a phenotype including conditional knockouts to model human disease

Confirm your results

We provide truly isogenic cell line pairs. Each cell model comes with the parental cell line as an additional control

Knockout and knock-in models

Our knock in models have more complex genetic modifications such as:

  • insertions
  • base pair changes
  • deletions
  • truncations
  • FLAG-tagged proteins for purification

Proven models

Our catalog of cell lines has become a gold-standard resourceciteab-award-cell-line-supplier-to-watch-in-cancer-research in antibody validation, cancer research, and early drug-discovery research. Horizon was recently recognized by CiteAb as the Cell Line Supplier to Watch in Cancer Research for 2024. Read more about the CiteAb award.

 

Limited use agreement

All cell lines engineered by Horizon Discovery are purchased under the terms of our Limited Use Label License.