Fmr1 Knockout Rat

TGRS5390

Animal Model
Fmr1

Nomenclature
SD- Fmr1 tm1sage

Zygosity Genotype
Heterozygous Female Embryos

Colony Size
Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
This model contains a deletion of the Fragile X mental retardation 1 gene (Fmr1). Mutations in Fmr1 result in Fragile X syndrome, the leading monogenic cause of autism, making this rat useful for the study of both Fragile X syndrome and autism.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Autism
• Fragile X syndrome
Research Area
Autism

Characteristics

Characteristics
• This model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization by Dr. Richard Paylor at Baylor College of Medicine
• Preliminary results suggest Fmr1 knockout rats possess perseverative chewing behavior and decreased juvenile play
• Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
• An expansion of CGG trinucleotide repeat in Fmr1 has been implicated in Fragile X syndrome
Background Strain: Sprague-Dawley
Figure 1
Fmr1 Knockout Rat - Figure 1
Figure 1: Loss of FMRP protein in Fmr1 knockout rats
FMRP protein expression is disrupted in Fmr1 knockout rats as compared to wild type controls as demonstrated by Western blot.
Actin staining demonstrates equal sample loading.
Protocols & Documents
Additional Information

Additional Information

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