ERBB2 (HER2) Expression IHC Reference Standard [DISCONTINUED]

NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu

Format Type
Biomarker Specific

FFPE section on slide

The ERBB2 (HER2) Reference Standard is a highly-characterized, biologically-relevant quality control material with negative (-), low positive (1+), intermediate positive (2+) and strong positive (3+) controlled protein expressing cell lines which can be utilised to test the analytical (technical) performance of your assay.

This product is not compatible for use in FISH.

Availability: Discontinued

Bulk order discount
Technical Information
The availability of precisely defined reference materials offers an industry standard for development and quality control of IHC assays, improving the accuracy and reproducibility. IHC HDx Reference Standards provide laboratories with a consistent source of positive and negative reference material on one slide.

• Precisely defined negative (-), low positive (+), intermediate positive (++) and strong positive (+++) protein expressing cell lines on the same slide (Onslide control)
• Cell lines verified by IHC assay and Quantitative Digital Pathology (QDP).

• Test the analytical (technical) performance of your assay with external controls of precisely defined human cell lines that express protein at a range of known levels
• Establish the practical lower limit of detection of your IHC methodology with validated low protein expressing cells
• Develop a new IHC protocol with a reproducible assay that is validated through reproducible cell lines
• Guide the evaluation of antibodies based on their sensitivity and specificity
• Gain additional confidence when optimizing and monitoring the performance of your assay through application of a consistent reference standard

Technical Data

The following tests are run as standard to ensure the quality of our IHC Reference Standards:
• Protein expression confirmed using biomarker specific IHC assay.
• Negative (-), low positive (+), intermediate positive (++) and strong positive (+++) cell line cores assessed using Quantitative Digital Pathology
Mutation Type
Fixation Method
10% Formalin
Core Diameter
Cell Density
1-1.5 x 104 cells/core dependent on cell size
Microscope Slide
Superfrost Plus

Product Information

Intended Use
For routine performance monitoring (Research Use Only)
Unit Size
5 slides per pack

General Information

15 months


Core 1
Core 2
Core 3
Core 4
Protocols & Documents

Please browse our collection of downloads below.

If you need any support, advice or additional documentation then don't hesitate to contact us here.

Certificate of Analysis

Batch ID: 22309
PDF Download

Documents & Related Literature

Safety Data Sheet
PDF Download
Order & Delivery Information

Please see our terms and conditions of ordering.

If you need any support, advice or additional documentation then don't hesitate to contact us here.

Order Information

We accept orders using the following methods:


Our online catalog and ordering system can be used to search our full menu of available HDx™ Reference Standards. Select your desired reference standards and add them to the shopping basket. Your order can be submitted instantly using credit card, telephone ordering or a purchase order number as the preferred payment method.


If you prefer to send us orders outside our online ordering system, please see the Contact Us page for telephone, fax, and email details in order to place an order.  We recommend that you use our online system to identify the products you require and their respective “HD” product codes. To order offline we will require the following information:

  • Product code(s) of the item(s) you wish to order (e.g. "HD123")
  • Your name, email address, title and organization
  • Shipping address and billing address with contact names
  • Purchase Order number if you have one
  • Telephone number
  • VAT Number (European Countries only)

Shipping Information

Shipping information for all territories can be found on our Shipping Charges page. This includes Shipping and Handling fees, as well as shipping conditions for each product range.

If you’re having trouble ordering or finding what you’re looking for, or if you require something we don’t yet offer, please see below for more information: 

Contact Us Terms of Ordering


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