Disc1 Knockout Rat

TGRA6370

Animal Model
Disc1

Nomenclature
SD- Disc1 tm1sage

Zygosity Genotype
Cryopreserved as heterozygous embryos

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein. A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish family. This model is useful in the study of schizophrenia.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve

Research Applications

Research Application
• Schizophrenia
• Bipolar disorder
• Neuronal growth and transport studies
Research Area
Schizophrenia

Characteristics

Characteristics
• Disc1 is involved in neuronal growth and cortical development
• The protein also regulates the proliferation of embryonic and adult neuronal progenitor cells through the GSK3/ß-catenin pathway
• Preliminary reports suggest impaired prepulse inhibition in Disc1 knockout rats
Background Strain: Sprague-Dawley
Figure 1
Disc1 Knockout Rat - Figure 1
Figure 1: Disc1 knockout rats display impaired pre-pulse inhibition.
Disc1 knockout rats showed significantly reduced pre-pulse inhibition at 3 and 6 db compared to wild type control rats.
Data courtesy of Pfizer NeuroBehavioral Core, Cambridge, MA
Additional Information

Additional Information

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