Horizon and Promega Corporation have partnered in a long-term relationship to develop a suite of best-in-class endogenous pathway tag and reporter cell lines for application in functional genomics research and drug discovery and development.
X-MAN reporter kits enable functional cell-based assays to be carried out at the endogenous level, allowing researchers to examine natural levels of protein and promoter activity. Traditional methods of understanding protein/promoter function have used exogenous plasmid based overexpression systems which can result in artefactual results. Endogenous pathway tag and reporter cell lines allow researchers a much higher level of confidence that their experimental results accurately reflect the changes seen in real disease biology.
Horizon also offers a range of Turbo-GFP tagged isogenic cell line pairs for applications where rapid appearance of bright fluorescence is crucial, such as cell and organelle labelling or tracking promoter activity.