ApoE Knockout Rabbit

TGON0001

Animal Model
ApoE

Nomenclature
NZW- ApoE tm1sage

Zygosity Genotype
Homozygous

Colony Size
Discontinued

$475.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

Request a quote
OR
Technical Information
Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making it an excellent model of human heart disease.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)

Research Applications

Research Application
• Atherogenesis
• Atherosclerosis
• Hypertension
• Insulin resistance
• Lipoprotein/Cholesterol transportation
• Metabolism (Triglyceride/Cholesterol)
• Obesity
• Type II diabetes
Research Area
Uptake Transporters

Characteristics

Characteristics
• 8 bp deletion within Exon 3
• Homozygous knockouts exhibit complete loss of ApoE protein via Western blot
• At four months of age, ApoE knockout rabbits demonstrate serum cholesterol levels 2-5x greater than wildtype
• At four and five months of age, ApoE knockout rabbits demonstrate triglyceride levels up to 2x greater than wildtype
Background Strain: New Zealand White
Figure 1
ApoE Knockout Rabbit - Figure 1
Figure 1: 4-Month old ApoE knockout rabbits on normal diet display increased serum cholesterol levels as compared to wild type animals
Protocols & Documents
Additional Information

Additional Information

Reviews

Write Your Own Review

You're reviewing: ApoE Knockout Rabbit

How do you rate this product? *

 
1 1 star
2 2 star
3 3 star
4 4 star
5 5 star
Price
Value
Quality
Back to top