DNA Repair
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Essential for the stability of life is the ability to faithfully duplicate the genome during cellular replication and combat environmental insults that constantly bombard the integrity of DNA in quiescent cells. To achieve this stability, human cells possess specific mechanisms that enable them to repair virtually any type of DNA-lesion. These DNA-repair mechanisms often overlap with recombinatorial, genomic stability and telomere maintenance pathways; and thus defects in DNA-repair can lead to elevated mutational rates and higher rates of cancer development. Encouragingly, these defects may offer ’Achilles heels’ for exploitation by novel cancer therapeutics that display ‘synthetic lethality’ in these compromised genetic backgrounds; as highlighted recently by the selective toxicity of Parp-inhibitors in BRCA-2 null cancers (see below).
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Horizon Offering |
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Horizon Discovery has a wide range of isogenic models available for immediate licensing or purchasing (learn more) and; can also develop custom isogenic models (learn more) or screen drug candidates against your specific gene target (learn more). |
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Additional data-sets are available for each application and can be shared under confidential disclosure agreement. Please contact us for more information. |
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References
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