All Publications

• Nature 2012 April (483) 100-103

• Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

• Anirudh Prahallad, Chong Sun, Sidong Huang, Federica Di Nicolantonio, Ramon Salazar, Davide Zecchin, Roderick L. Beijersbergen, Alberto Bardelli and Rene Bernards

• View Article

• Proc Natl Acad Sci U S A.  2011 December (Epub ahead of print)

• Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia

• Bottos A, Martini M, Di Nicolantonio F, Comunanza V, Maione F, Minassi A, Appendino G, Bussolino F, Bardelli A

• View Article

• Proc Natl Acad Sci U S A 2011 September (109)

• Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

• Konishi H, Mohseni M, Tamaki A, Garay JP, Croessmann S, Karnan S, Ota A, Wong HY, Konishi Y, Karakas B, Tahir K, Abukhdeir AM, Gustin JP, Cidado J, Wang GM, Cosgrove D, Cochran R, Jelovac D, Higgins MJ, Arena S, Hawkins L, Lauring J, Gross AL, Heaphy CM, Hosokawa Y, Gabrielson E, Meeker AK, Visvanathan K, Argani P, Bachman KE, Park BH.

• View Article

• JAMA 2010 October (304) 1812-1820

• Association of KRAS p.G13D Mutation With Outcome in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer Treated With Cetuximab

• Roock WD, Jonker DJ, Di Nicolantonio F, Sartore-Bianchi A, Tu D, Siena S, Lamba S, Arena S, Frattini M, Piessevaux H, Cutsem EV, O'Callaghan CJ, Khambata-Ford S, Zalcberg JR, Simes J, Karapetis CS, Bardelli A, Tejpar S

• View Article

• Science 2010 September (273) 1386-9.

• Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide.

• Cole-Strauss A, Yoon K, Xiang Y, Byrne BC, Rice MC, Gryn J, Holloman WK, Kmiec EB.

• View Article

• Nucleic Acids Res. 2010 September (36) e127

• Epitope tagging of endogenous genes in diverse human cell lines.

• Kim JS, Bonifant C, Bunz F, Lane WS, Waldman T.

• View Article

• AACR 2010 September (Poster Session)

• Mutant PIK3CA increases the expression of individual tubulin isoforms and promotes resistance to anti-mitotic chemotherapy drugs

• Genentech

• View Article

• Impact of the new biology: From genomics to personalized medicine

• Darrin M Disley

• View Article

• Oncogene 2010 August (25) 2048-59

• CDX2 does not suppress tumorigenicity in the human gastric cancer cell line MKN45.

• Dang LH, Chen F, Knock SA, Huang EH, Feng J, Appelman HD, Dang DT.

• View Article

• Cancer Res.  2010 August (66) 6018-24

• Haploinsufficiency of RAD51B causes centrosome fragmentation and aneuploidy in human cells.

• Date O, Katsura M, Ishida M, Yoshihara T, Kinomura A, Sueda T, Miyagawa K.

• View Article

• Oncogene 2010 August (25) 2264-72

• CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48.

• Dang LH, Chen F, Ying C, Chun SY, Knock SA, Appelman HD, Dang DT.

• View Article

• Cancer Res. 2010 August (65) 9485-94

• Glutathione S-transferase pi1 promotes tumorigenicity in HCT116 human colon cancer cells.

• Dang DT, Chen F, Kohli M, Rago C, Cummins JM, Dang LH.

• View Article

• Cell 2010 August (106) 287-96

• Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin.

• Dhar SK, Yoshida K, Machida Y, Khaira P, Chaudhuri B, Wohlschlegel JA, Leffak M, Yates J, Dutta A.

• View Article

• J Clin Invest.  2010 August (120) 2858-66

• Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus.

• Di Nicolantonio F, Arena S, Tabernero J, Grosso S, Molinari F, Macarulla T, Russo M, Cancelliere C, Zecchin D, Mazzucchelli L, Sasazuki T, Shirasawa S, Geuna M, Frattini M, Baselga J, Gallicchio M, Biffo S, Bardelli A.

• View Article

• Clin Cancer Res.  2010 July (16) 3670-83

• Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.

• O'Brien C, Wallin JJ, Sampath D, GuhaThakurta D, Savage H, Punnoose EA, Guan J, Berry L, Prior WW, Amler LC, Belvin M, Friedman LS, Lackner MR.

• View Article

• Nature 2010 May (464) 431-5

• RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

• Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S.

• View Article

• Molecular Therapy 2010 May (18) 983-986

• Frequent Endonuclease Cleavage at Off-target Locations In Vivo

• Lisa M Petek, David W Russell and Daniel G Miller

• View Article

• Oncogene 2010 April (29) 2337-45

• Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations.

• Lauring J, Cosgrove DP, Fontana S, Gustin JP, Konishi H, Abukhdeir AM, Garay JP, Mohseni M, Wang GM, Higgins MJ, Gorkin D, Reis M, Vogelstein B, Polyak K, Cowherd M, Buckhaults PJ, Park BH.

• View Article

• AACR 2010 April (Poster Session)

• Endogenous expression of oncogenic PI3K mutation leads to accumulation of anti-apoptotic proteins at mitochondria

• Mitologics Ltd.

• View Article

• AACR 2010 April (Poster Session)

• The use of X-MAN isogenic cell lines to define PI3-kinase inhibitor activity profiles

• Hypoxium Ltd.

• View Article

• Nat Rev Cancer  2010 April (10) 241-53

• Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents.

• Sharma SV, Haber DA, Settleman J.

• View Article

• PLoS One.  2010 March (5) e9924

• Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.

• Buron N, Porceddu M, Brabant M, Desgué D, Racoeur C, Lassalle M, Péchoux C, Rustin P, Jacotot E, Borgne-Sanchez A.

• View Article

• J Clin Oncol. 2010 March (28) 1181-9

• Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer.

• Bardelli A, Siena S.

• View Article

• Proc Natl Acad Sci. 2010 March (104) 4383-8

• Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.

• Burkard ME, Randall CL, Larochelle S, Zhang C, Shokat KM, Fisher RP, Jallepalli PV.

• View Article

• PLoS Genet. 2010 February (6) e1000855

• Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells.

• Fattah F, Lee EH, Weisensel N, Wang Y, Lichter N, Hendrickson EA.

• View Article

• Proc Natl Acad Sci U S A.  2010 February (107) 2598-603

• Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.

• Ericson K, Gan C, Cheong I, Rago C, Samuels Y, Velculescu VE, Kinzler KW, Huso DL, Vogelstein B, Papadopoulos N.

• View Article

• Cell  2010 January (140) 209-21

• Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.

• Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, Hussain J, Reis-Filho JS, Springer CJ, Pritchard C, Marais R.

• View Article

• Nature  2009 November (462) 231-4

• Cohesin acetylation speeds the replication fork.

• Terret ME, Sherwood R, Rahman S, Qin J, Jallepalli PV.

• View Article

• Cancer Res.  2009 November (69) 8275-83

• Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells.

• Vitolo MI, Weiss MB, Szmacinski M, Tahir K, Waldman T, Park BH, Martin SS, Weber DJ, Bachman KE.

• View Article

• J Natl Cancer Inst.  2009 October (101) 1308-24

• Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer.

• Siena S, Sartore-Bianchi A, Di Nicolantonio F, Balfour J, Bardelli A.

• View Article

• PLoS One 2009 October (4) e7287

• Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer.

• Sartore-Bianchi A, Di Nicolantonio F, Nichelatti M, Molinari F, De Dosso S, Saletti P, Martini M, Cipani T, Marrapese G, Mazzucchelli L, Lamba S, Veronese S, Frattini M, Bardelli A, Siena S.

• View Article

• Science.  2009 September (325) 1555-9

• Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.

• Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA Jr, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B, Papadopoulos N.

• View Article

• EORTC  2009 September (Poster Session)

• Endogenous expression of an oncogenic PI3K mutation leads to activated PI3K pathway signalling and an invasive phenotype

• Genentech Inc

• View Article

• EMBO Mol Med.  2009 September (1) 315-22

• Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.

• Mendes-Pereira AM, Martin SA, Brough R, McCarthy A, Taylor JR, Kim JS, Waldman T, Lord CJ, Ashworth A.

• View Article

• Proc Natl Acad Sci U S A.  2009 July (106) 12430-5

• Ku86 represses lethal telomere deletion events in human somatic cells.

• Wang Y, Ghosh G, Hendrickson EA.

• View Article

• Proc Natl Acad Sci U S A.  2009 May (106) 3964-9

• A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53.

• Sur S, Pagliarini R, Bunz F, Rago C, Diaz LA Jr, Kinzler KW, Vogelstein B, Papadopoulos N.

• View Article

• Nature  2009 May (458) 725-31

• Tumours with PI3K activation are resistant to dietary restriction.

• Kalaany NY, Sabatini DM

• View Article

• Cancer Res.  2009 May (69) 1851-7

• PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies.

• Sartore-Bianchi A, Martini M, Molinari F, Veronese S, Nichelatti M, Artale S, Di Nicolantonio F, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S, Bardelli A.

• View Article

• Proc Natl Acad Sci U S A. 2009 February (106) 2835-40

• Knockin of mutant PIK3CA activates multiple oncogenic pathways.

• Gustin JP, Karakas B, Weiss MB, Abukhdeir AM, Lauring J, Garay JP, Cosgrove D, Tamaki A, Konishi H, Konishi Y, Mohseni M, Wang G, Rosen DM, Denmeade SR, Higgins MJ, Vitolo MI, Bachman KE, Park BH.

• View Article

• Proc Natl Acad Sci U S A.  2008 December (105) 20864-9

• Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses.

• Di Nicolantonio F, Arena S, Gallicchio M, Zecchin D, Martini M, Flonta SE, Stella GM, Lamba S, Cancelliere C, Russo M, Geuna M, Appendino G, Fantozzi R, Medico E, Bardelli A.

• View Article

• Proc Natl Acad Sci U S A.  2008 December (105) 20752-7

• Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control.

• Wilsker D, Petermann E, Helleday T, Bunz F.

• View Article

• J Clin Oncol.  2008 December (26) 5705-12.

• Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.

• Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S, Bardelli A.

• View Article

• J Clin Oncol.  2008 December (26) 5705-12

• Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.

• Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S, Bardelli A.

• View Article

• Mol Cell.  2008 December (32) 662-72

• Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells.

• Merrick KA, Larochelle S, Zhang C, Allen JJ, Shokat KM, Fisher RP.

• View Article

• Mol Cell Biol.  2008 October (28) 6182-95

• The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells.

• Ruis BL, Fattah KR, Hendrickson EA.

• View Article

• J Biol Chem.  2008 September (283) 26428-35

• Identification and characterization of a diamine exporter in colon epithelial cells.

• Uemura T, Yerushalmi HF, Tsaprailis G, Stringer DE, Pastorian KE, Hawel L 3rd, Byus CV, Gerner EW.

• View Article

• Business Weekly  2008 July ()

• Personalized Medicine: A fine wine matures

• Business Weekly

• View Article

• Cancer Res.  2008 July (68) 5023-30

• A syngeneic variance library for functional annotation of human variation: application to BRCA2.

• Hucl T, Rago C, Gallmeier E, Brody JR, Gorospe M, Kern SE.

• View Article

• Proc Natl Acad Sci U S A.  2008 June (105) 8703-8

• Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells.

• Fattah FJ, Lichter NF, Fattah KR, Oh S, Hendrickson EA.

• View Article

• J Cell Biol. 2008 Jun 16;181(6):913-20. 2008 June (181) 913-20

• Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase.

• Grim JE, Gustafson MP, Hirata RK, Hagar AC, Swanger J, Welcker M, Hwang HC, Ericsson J, Russell DW, Clurman BE.

• View Article

• DNA Repair (Amst) 2008 June (7) 762-74

• Mutations to Ku reveal differences in human somatic cell lines.

• Fattah KR, Ruis BL, Hendrickson EA.

• View Article

• Cell Cycle 2008 May (7) 1184-90

• The nucleolar phosphatase Cdc14B is dispensable segregation and mitotic exit in human cells

• Berdougo E, Nachury MV, Jackson PK, Jallepalli PV.

• View Article

• J. Clin. Invest. 2008 April (118) 1571-7

• Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer.

• Rogers CS, Hao Y, Rokhlina T, Samuel M, Stoltz DA, Li Y, Petroff E, Vermeer DW, Kabel AC, Yan Z, Spate L, Wax D, Murphy CN, Rieke A, Whitworth K, Linville ML, Korte SW, Engelhardt JF, Welsh MJ, Prather RS.

• View Article

• J. Clin. Invest. 2008 April ( 118) 1578–1583

• Adeno-associated virus–targeted disruption of the CFTR gene in cloned ferrets

• Sun X, Yan Z, Yi Y, Li Z, Lei D, Rogers CS, Chen J, Zhang Y, Welsh MJ, Leno GH, Engelhardt JF.

• View Article

• Proc Natl Acad Sci U S A.  2008 March (105) 3443-8

• Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.

• Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, Shen D, Barrett I, Nouhi Y, Spencer F, Markowitz S, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C, Hieter P.

• View Article

• Mol Ther 2008 January (16) 187-93

• Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta.

• Chamberlain JR, Deyle DR, Schwarze U, Wang P, Hirata RK, Li Y, Byers PH, Russell DW.

• View Article

• Biol Proced Online  2007 December (9) 84-90

• Development of human gene reporter cell lines using rAAV mediated homologous recombination.

• Fernandez SL, Russell DW, Hurlin PJ.

• View Article

• Biol Proced Online. 2007 December (9) 84-90

• Development of human gene reporter cell lines using rAAV mediated homologous recombination

• Fernandez SL, Russell DW, Hurlin PJ.

• View Article

• Pharmacogenomics. 2007 Dec;8(12):1629-33. 2007 December ()

• Genomic landscapes of cancers: prospects for targeted therapies

• Bleeker FE, Bardelli A.

• View Article

• J Mol Biol.  2007 November (372) 397-406

• Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling.

• Jurvansuu J, Fragkos M, Ingemarsdotter C, Beard P.

• View Article

• Cancer Res.  2007 September (67) 8468-76

• Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers.

• Arena S, Isella C, Martini M, de Marco A, Medico E, Bardelli A.

• View Article

• Cancer Res.  2007 September (67) 8460-7

• Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation.

• Konishi H, Karakas B, Abukhdeir AM, Lauring J, Gustin JP, Garay JP, Konishi Y, Gallmeier E, Bachman KE, Park BH.

• View Article

• Proc Natl Acad Sci U S A.  2007 July (104) 11412-7

• Genetic targeting of the kinase activity of the Met receptor in cancer cells.

• Arena S, Pisacane A, Mazzone M, Comoglio PM, Bardelli A.

• View Article

• Cancer Res.  2007 May (67) 3545-50

• Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma.

• Balakrishnan A, Bleeker FE, Lamba S, Rodolfo M, Daniotti M, Scarpa A, van Tilborg AA, Leenstra S, Zanon C, Bardelli A.

• View Article

• Cancer Biol Ther.  2007 May (6) 654-60

• Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer

• Gallmeier E, Hucl T, Calhoun ES, Cunningham SC, Bunz F, Brody JR, Kern SE.

• View Article

• Oncogene 2007 April (26) 2535-42

• Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation.

• Hurley PJ, Wilsker D, Bunz F.

• View Article

• Mol Cancer Ther. 2007 April (6) 1406-13

• Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival.

• Wilsker D, Bunz F.

• View Article

• Cancer Res.  2007 March (67) 2643-8

• Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies.

• Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, Zanon C, Moroni M, Veronese S, Siena S, Bardelli A.

• View Article

• Proc Natl Acad Sci U S A.  2007 March (104) 4054-9

• The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage.

• Wang P, Yu J, Zhang L.

• View Article

• Cancer Res.  2007 March (67) 2169-77

• High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells.

• Gallmeier E, Hucl T, Brody JR, Dezentje DA, Tahir K, Kasparkova J, Brabec V, Bachman KE, Kern SE.

• View Article

• Proc Natl Acad Sci U S A.  2007 February (98) 2598-603

• Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells.

• Park BH, Vogelstein B, Kinzler KW.

• View Article

• Mol Ther.  2007 January (15) 1740

• AAV Vectors, Insertional Mutagenesis, and Cancer

• David W Russell

• View Article

• Mol Cancer Ther. 2007 January (6) 269-76

• Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.

• Sarthy AV, Morgan-Lappe SE, Zakula D, Vernetti L, Schurdak M, Packer JC, Anderson MG, Shirasawa S, Sasazuki T, Fesik SW.

• View Article

• Mol Cell Biol. 2007 January (27) 662-77

• Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.

• Kim JS, Lee C, Bonifant CL, Ressom H, Waldman T.

• View Article

• Nucleic Acids Res.  2006 December (35) E9

• Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination.

• Shiomi N, Mori M, Tsuji H, Imai T, Inoue H, Tateishi S, Yamaizumi M, Shiomi T.

• View Article

• Radiat Res.  2006 December (167) 66-79

• The lethality of Ku86 (XRCC5) loss-of-function mutations in human cells is independent of p53 (TP53).

• Ghosh G, Li G, Myung K, Hendrickson EA.

• View Article

• Biotechniques  2006 September (41) 311-6

• Simple one-week method to construct gene-targeting vectors: application to production of human knockout cell lines.

• Iiizumi S, Nomura Y, So S, Uegaki K, Aoki K, Shibahara K, Adachi N, Koyama H.

• View Article

• Nucleic Acids Res.  2006 July (34) 3345-60

• Homologous recombination is required for AAV-mediated gene targeting.

• Vasileva A, Linden RM, Jessberger R.

• View Article

• Science.  2006 June (312) 1650-3

• p53 regulates mitochondrial respiration.

• Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM.

• View Article

• Gastroenterology 2006 June (130) 2145-54

• Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.

• Gallmeier E, Calhoun ES, Rago C, Brody JR, Cunningham SC, Hucl T, Gorospe M, Kohli M, Lengauer C, Kern SE

• View Article

• Cancer Res.  2006 June (66) 5560-4

• Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss.

• Cunningham SC, Gallmeier E, Hucl T, Dezentje DA, Calhoun ES, Falco G, Abdelmohsen K, Gorospe M, Kern SE.

• View Article

• Genes Cells 2006 March (11) 363-71

• Enhanced gene targeting efficiency by siRNA that silences the expression of the Bloom syndrome gene in human cells.

• So S, Nomura Y, Adachi N, Kobayashi Y, Hori T, Kurihara Y, Koyama H.

• View Article

• Proc Natl Acad Sci U S A. .  2006 March (103) 3687-92

• The colorectal microRNAome.

• Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE.

• View Article

• DNA Repair (Amst)  2006 March (5) 303-11

• Heterozygous inactivation of human Ku70/Ku86 heterodimer does not affect cell growth, double-strand break repair, or genome integrity.

• Uegaki K, Adachi N, So S, Iiizumi S, Koyama H.

• View Article

• Nucleic Acids Res.  2006 February (34) 880-92

• Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells.

• Hiyama T, Katsura M, Yoshihara T, Ishida M, Kinomura A, Tonda T, Asahara T, Miyagawa K.

• View Article

• Cancer Res.  2006 February (66) 1684-936

• Hypoxia-inducible factor-1alpha promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts.

• Dang DT, Chen F, Gardner LB, Cummins JM, Rago C, Bunz F, Kantsevoy SV, Dang LH.

• View Article

• Curr Opin Oncol.  2006 January (18) 69-76

• Kinase mutations in cancer: chinks in the enemy's armour?

• Di Nicolantonio F, Bardelli A

• View Article

• DNA Cell Biol.  2006 January (25) 19-24

• The human pre-B cell line Nalm-6 is highly proficient in gene targeting by homologous recombination.

• Adachi N, So S, Iiizumi S, Nomura Y, Murai K, Yamakawa C, Miyagawa K, Koyama H.

• View Article

• Nucleic Acids Res.  2005 October (33) e158

• Improved methods for the generation of human gene knockout and knockin cell lines.

• Topaloglu O, Hurley PJ, Yildirim O, Civin CI, Bunz F.

• View Article

• Nat Cell Biol. 2005 Oct;7(10):930-2.  2005 September (7) 930-2

• Multiple roles for separase auto-cleavage during the G2/M transition.

• Papi M, Berdougo E, Randall CL, Ganguly S, Jallepalli PV.

• View Article

• Nature  2005 June (435) 646-51

• Highly efficient endogenous human gene correction using designed zinc-finger nucleases.

• Urnov FD, Miller JC, Lee YL, Beausejour CM, Rock JM, Augustus S, Jamieson AC, Porteus MH, Gregory PD, Holmes MC.

• View Article

• Cancer Cell.  2005 June (7) 561-73

• Mutant PIK3CA promotes cell growth and invasion of human cancer cells.

• Samuels Y, Diaz LA Jr, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE.

• View Article

• Lancet Oncol.  2005 May (6) 257-8

• Who will benefit from treatment against EGFR?

• Arribas J, Baselga J.

• View Article

• Hum Gene Ther. 2005 March (16) 522-6

• Gene targeting by adeno-associated virus vectors is cell-cycle dependent.

• Trobridge G, Hirata RK, Russell DW.

• View Article

• NAR 2005 January (35) 158

• Improved methods for the generation of human gene knockout and knockin cell lines

• Topaloglu O, Hurley PJ, Yildirim O, Civin CI, Bunz F.

• View Article

• J Biol Chem.  2004 December (279) 55433-42

• Genetic interactions between BLM and DNA ligase IV in human cells.

• So S, Adachi N, Lieber MR, Koyama H

• View Article

• Proc Natl Acad Sci U S A.  2004 November (101) 16897-902

• SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells.

• Kohli M, Yu J, Seaman C, Bardelli A, Kinzler KW, Vogelstein B, Lengauer C, Zhang L.

• View Article

• Cancer Res.  2004 October (64) 6906-14

• PTEN gene targeting reveals a radiation-induced size checkpoint in human cancer cells.

• Lee C, Kim JS, Waldman T.

• View Article

• Cancer Res.  2004 May (64) 3006-8

• X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells.

• Cummins JM, Kohli M, Rago C, Kinzler KW, Vogelstein B, Bunz F.

• View Article

• Nature  2004 April (428) 1 p following 486.

• Tumour suppression: disruption of HAUSP gene stabilizes p53.

• Cummins JM, Rago C, Kohli M, Kinzler KW, Lengauer C, Vogelstein B.

• View Article

• J Virol. 2004 March (78) 4165-75

• Targeted correction of single-base-pair mutations with adeno-associated virus vectors under nonselective conditions.

• Liu X, Yan Z, Luo M, Zak R, Li Z, Driskell RR, Huang Y, Tran N, Engelhardt JF.

• View Article

• Cancer Res.  2004 March (64) 1932-7

• B-Raf is dispensable for K-Ras-mediated oncogenesis in human cancer cells.

• Cancer Res. 2004 Mar 15;64(6):1932-7.

• View Article

• Nature  2004 March (428) 77-81

• Inactivation of hCDC4 can cause chromosomal instability.

• Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C.

• View Article

• Science 2004 February (303) 1198-201

• Gene targeting in stem cells from individuals with osteogenesis imperfecta.

• Chamberlain JR, Schwarze U, Wang PR, Hirata RK, Hankenson KD, Pace JM, Underwood RA, Song KM, Sussman M, Byers PH, Russell DW.

• View Article

• EMBO J.  2004 February (23) 670-680

• Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox.

• Zhen L, King AA, Xiao Y, Chanock SJ, Orkin SH, Dinauer MC.

• View Article

• EMBO J.  2004 February (23) 670-680

• XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells

• Takashi Yoshihara, Kiyoshi Miyagawa

• View Article

• Nucleic Acids Res.  2004 January (32) e3

• Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses.

• Kohli M, Rago C, Lengauer C, Kinzler KW, Vogelstein B.

• View Article

• Cancer Res.  2003 December (63) 8578-81

• Hyper-recombination and genetic instability in BLM-deficient epithelial cells

• Traverso G, Bettegowda C, Kraus J, Speicher MR, Kinzler KW, Vogelstein B, Lengauer C.

• View Article

• Cancer Biol Ther.  2003 December (2) 700-1

• Human somatic cell knockouts reveal determinants of sensitivity and resistance to proteasome inhibitor PS-341.

• Lee C, Waldman T.

• View Article

• J Virol.  2003 November (77) 13136-45

• Chromosomal integration and homologous gene targeting by replication-incompetent vectors based on the autonomous parvovirus minute virus of mice.

• Hendrie PC, Hirata RK, Russell DW.

• View Article

• Cancer Biol Ther.  2003 November (2) 679-84

• Haploinsufficiency of hTERT leads to telomere dysfunction and radiosensitivity in human cancer cells.

• Hauguel T, Bunz F

• View Article

• J Biol Chem.  2003 June (278) 20475-9

• The Chk2 tumor suppressor is not required for p53 responses in human cancer cells.

• Jallepalli PV, Lengauer C, Vogelstein B, Bunz F.

• View Article

• Mol Cell Biol.  2003 April (23) 3558-3565

• Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks

• Matthew H. Porteus, David Baltimore

• View Article

• Mol Cell Biol.  2003 April (23) 3550-7

• Human gene targeting by adeno-associated virus vectors is enhanced by DNA double-strand breaks.

• Miller DG, Petek LM, Russell DW.

• View Article

• Nat Biotechnol.  2003 February (21) 319-21

• Homologous recombination in human embryonic stem cells.

• Zwaka TP, Thomson JA.

• View Article

• Proc Natl Acad Sci U S A.  2003 February (100) 1931-6

• PUMA mediates the apoptotic response to p53 in colorectal cancer cells.

• Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L.

• View Article

• Curr Protoc Mol Biol. 2003 January () 9.15.1-9.15.2

• INACTIVATION OF GENES IN MAMMALIAN CELLS Human Somatic Cell Gene Targeting

• Todd Waldman, Carolyn Lee, Tagvor G. Nishanian, and Jung-Sik Kim

• View Article

• Cancer Cell.  2003 January (3) 89-95

• Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.

• Bachman KE, Park BH, Rhee I, Rajagopalan H, Herman JG, Baylin SB, Kinzler KW, Vogelstein B.

• View Article

• Mol Cancer Ther.  2002 December (1) 1355-9

• Proof-of-principle: oncogenic beta-catenin is a valid molecular target for the development of pharmacological inhibitors.

• Kim JS, Crooks H, Foxworth A, Waldman T.

• View Article

• Nucleic Acids Res.  2002 November (30) 4892-901

• A chromosomal position effect on gene targeting in human cells.

• Yáñez RJ, Porter AC.

• View Article

• Nature 2002 October (419) 944-7

• Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

• Faili A, Aoufouchi S, Flatter E, Guéranger Q, Reynaud CA, Weill JC.

• View Article

• EMBO J.  2002 September (16) 4809-19

• Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line.

• Cao Y, Janssen EM, Duncan AW, Altman A, Billadeau DD, Abraham RT.

• View Article

• Nat Immunol.  2002 August (3) 800-1

• AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line.

• Faili A, Aoufouchi S, Guéranger Q, Zober C, Léon A, Bertocci B, Weill JC, Reynaud CA.

• View Article

• Nat Biotechnol.  2002 June (20) 735-8

• Targeted transgene insertion into human chromosomes by adeno-associated virus vectors

• Roli Hirata, Joel Chamberlain, Rong Dong, and David W.Russell

• View Article

• Proc Natl Acad Sci U S A.  2002 June (99) 8265-70

• Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation.

• Chan TA, Wang Z, Dang LH, Vogelstein B, Kinzler KW.

• View Article

• Cancer Res.  2002 May (62) 2744-8

• Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells.

• Kim JS, Crooks H, Dracheva T, Nishanian TG, Singh B, Jen J, Waldman T.

• View Article

• Proc Natl Acad Sci U S A.  2002 May (99) 2848-53

• DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities.

• Zawel L, Yu J, Torrance CJ, Markowitz S, Kinzler KW, Vogelstein B, Zhou S.

• View Article

• Nature. 2002 April (416) 552-6

• DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.

• Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B.

• View Article

• Nucleic Acids Res.  2002 January (30) 740-8

• Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell line.

• Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell line.

• View Article

• Proc Natl Acad Sci USA. 2002 January (99) 832-7

• Ku86 is essential in human somatic cells.

• Li G, Nelsen C, Hendrickson EA.

• View Article

• EMBO J.  2002 January (21) 175-80

• A role for RAD54B in homologous recombination in human cells.

• Miyagawa K, Tsuruga T, Kinomura A, Usui K, Katsura M, Tashiro S, Mishima H, Tanaka K.

• View Article

• Science 2001 November (294) 1713-6

• ATR and ATRIP: partners in checkpoint signaling.

• Cortez D, Guntuku S, Qin J, Elledge SJ

• View Article

• Nature Biotech. 2001 October (19) 919-20

• Knockout drug screens: Cell lines that differ by a single genetic change show promise in drug screens to identify compounds with gene-selective properties.

• George C. Prendergast

• View Article

• Nat Biotechnol.  2001 October (19) 940-5

• Use of isogenic human cancer cells for high-throughput screening and drug discovery.

• Torrance CJ, Agrawal V, Vogelstein B, Kinzler KW.

• View Article

• Nat Med.  2001 October (7) 1111-7

• Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells.

• Hwang PM, Bunz F, Yu J, Rago C, Chan TA, Murphy MP, Kelso GF, Smith RA, Kinzler KW, Vogelstein B.

• View Article

• Cell. 2001 May 18;105(4):445-57. 2001 May (105) 445-57

• Securin is required for chromosomal stability in human cells.

• Jallepalli PV, Waizenegger IC, Bunz F, Langer S, Speicher MR, Peters JM, Kinzler KW, Vogelstein B, Lengauer C.

• View Article

• Ann Surg 2001 May (233) 696-703

• High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells.

• Sohn TA, Su GH, Ryu B, Yeo CJ, Kern SE.

• View Article

• Mol Ther. 2001 March (3) 526-30

• Introduction of single base substitutions at homologous chromosomal sequences by adeno-associated virus vectors.

• Inoue N, Dong R, Hirata RK, Russell DW.

• View Article

• Science  2000 November (290) 989-92

• Role of BAX in the apoptotic response to anticancer agents.

• Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B

• View Article

• Genes Dev.  2000 July (14) 1584-1588

• Cooperative effects of genes controlling the G2/M checkpoint

• Timothy A. Chan, Paul M. Hwang, Heiko Hermeking, Kenneth W. Kinzler, and Bert Vogelstein

• View Article

• J Virol.  2000 May (74) 4612-20

• Design and packaging of adeno-associated virus gene targeting vectors.

• Hirata RK, Russell DW.

• View Article

• Nature.  2000 April (404) 1003-7

• CpG methylation is maintained in human cancer cells lacking DNMT1.

• Rhee I, Jair KW, Yen RW, Lengauer C, Herman JG, Kinzler KW, Vogelstein B, Baylin SB, Schuebel KE.

• View Article

• J Virol.  1999 November (73) 7376-80

• High-fidelity correction of mutations at multiple chromosomal positions by adeno-associated virus vectors.

• Inoue N, Hirata RK, Russell DW.

• View Article

• Nat Biotechnol. 1999 October (17) 989-93

• Correction of chromosomal point mutations in human cells with bifunctional oligonucleotides.

• Culver KW, Hsieh WT, Huyen Y, Chen V, Liu J, Khripine Y, Khorlin A.

• View Article

• Nature  1999 October (401) 616-20

• 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.

• Nature. 1999 Oct 7;401(6753):616-20.

• View Article

• Gene Ther.  1999 June (6) 1282-90

• Gene targeting is enhanced in human cells overexpressing hRAD51.

• Yáñez RJ, Porter AC.

• View Article

• Somat Cell Mol Genet. 1998 December (25) 27-31

• Influence of DNA delivery method on gene targeting frequencies in human cells.

• Yáñez RJ, Porter AC

• View Article

• Hum Mol Genet.  1998 October (7) 1913-9

• Targeted replacement of normal and mutant CFTR sequences in human airway epithelial cells using DNA fragments.

• Goncz KK, Kunzelmann K, Xu Z, Gruenert DC.

• View Article

• Mol Cell.  1998 October (2) 477-84

• DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.

• Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber MR.

• View Article

• Proc Natl Acad Sci U S A.  1998 May (95) 2412-6

• Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.

• Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL, Kern SE, Kinzler KW, Vogelstein B.

• View Article

• Nature Genetics 1998 January (18) 325

• Human gene targeting by viral vectors

• David W. Russel & Roli K. Hirata

• View Article

• Science 1997 August (277) 831-4

• Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts.

• Brown JP, Wei W, Sedivy JM.

• View Article

• Hepatology. 1997 June (25) 1462-8

• Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide.

• Kren BT, Cole-Strauss A, Kmiec EB, Steer CJ.

• View Article

• J Cell Physiol.  1997 April (170) 299-308

• Gene targeting of a CFTR allele in HT29 human epithelial cells.

• Montrose-Rafizadeh C, Kole J, Bartkowski LM, Lee LH, Blackmon DL, Behnken SE, Gearhart JD, Cohn JA, Montrose MH.

• View Article

• Nat Genet.  1997 February (15) 258-65

• Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA.

• Itzhaki JE, Gilbert CS, Porter AC.

• View Article

• Gene Ther.  1996 October (3) 859-67

• Gene targeting of CFTR DNA in CF epithelial cells.

• Kunzelmann K, Legendre JY, Knoell DL, Escobar LC, Xu Z, Gruenert DC.

• View Article

• Genes Dev.  1996 July (10) 1945-52

• Genetic determinants of p53-induced apoptosis and growth arrest.

• Polyak K, Waldman T, He TC, Kinzler KW, Vogelstein B.

• View Article

• Cancer Res.  1996 May (56) 2250-5

• Repair Defect in p21 WAF1/CIP1 -/- human cancer cells.

• McDonald ER 3rd, Wu GS, Waldman T, El-Deiry WS.

• View Article

• Cancer Res.  1995 November (55) 5187-90

• p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

• Waldman T, Kinzler KW, Vogelstein B.

• View Article

• Nucleic Acids Res.  1995 July (23) 2784-90

• The effect of target site transcription on gene targeting in human cells in vitro.

• Thyagarajan B, Johnson BL, Campbell C.

• View Article

• Proc Natl Acad Sci U S A. 1994 December (91) 11943-7

• Rapid detection of homologous recombinants in nontransformed human cells.

• Williams SR, Ousley FC, Vitez LJ, DuBridge RB.

• View Article

• J Immunol.  1993 July (151) 1528-34

• Targeted disruption of CD43 gene enhances T lymphocyte adhesion.

• Manjunath N, Johnson RS, Staunton DE, Pasqualini R, Ardman B.

• View Article

• Science 1993 April (262) 1734

• Association of the APC Tumor Suppressor Protein with Catenins

• Li-Kuo Su, Bert Vogelstein, Kenneth W. Kinzler

• View Article

• Science 1993 April (260) 85-8

• Altered growth of human colon cancer cell lines disrupted at activated Ki-ras.

• Shirasawa S, Furuse M, Yokoyama N, Sasazuki T.

• View Article

• Nat Genet. 1992 Dec;2(4):283-7. 1992 November (2) 283-7

• Targeted breakage of a human chromosome mediated by cloned human telomeric DNA.

• Itzhaki JE, Barnett MA, MacCarthy AB, Buckle VJ, Brown WR, Porter AC.

• View Article

• J Clin Invest. 1992 Jul;90(1):256-61. 1992 July (90) 256-61

• Modification of the apolipoprotein B gene in HepG2 cells by gene targeting.

• Farese RV Jr, Flynn LM, Young SG.

• View Article

• Proc Natl Acad Sci U S A.  1991 September (88) 8067-71

• Fidelity of targeted recombination in human fibroblasts and murine embryonic stem cells.

• Zheng H, Hasty P, Brenneman MA, Grompe M, Gibbs RA, Wilson JH, Bradley A.

• View Article

• Nucleic Acids Res.  1991 July (19) 3835-42

• Targeted disruption of a human interferon-inducible gene detected by secretion of human growth hormone.

• Itzhaki JE, Porter AC.

• View Article

• Genes Dev.  1990 January (4) 157-66

• Gene targeting at the human CD4 locus by epitope addition.

• Jasin M, Elledge SJ, Davis RW, Berg P.

• View Article

• Proc Natl Acad Sci U S A.  1987 October (84) 3820-4

• Accurate modification of a chromosomal plasmid by homologous recombination in human cells.

• Song KY, Schwartz F, Maeda N, Smithies O, Kucherlapati R.

• View Article

• Nature 1985 September (317) 230-4

• Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination.

• Smithies O, Gregg RG, Boggs SS, Koralewski MA, Kucherlapati RS.

• View Article