Custom Drug Profiling
Horizon is pleased to be able to offer its customers screening of compounds against any of its 150+ human isogenic cell models.
The following panel of genotypes are examples of those being routinely used to profile compounds for “patient-relevant” genotype selectivity in a range of 2D and 3D assay formats.
- Parental cell lines (HCT116, DLD1, SW48, MCF10A, HME)
- PIK3CA, EGFR, K-Ras, B-Raf, p53, PTEN, AKT, Beta-Catenin, DNMT, BRCA
- PIK3CA/EGRF double, K-Ras/PIK3CA double, EGFR /B-Raf double
Assays can be formatted in either an optimized 2D proliferation assay with a 10 point x 4 replicate dose response and / or a 3D culture or spheroid assay (or nominated customer alternative) over more limited concentration ranges. All data will be presented in an industry standard reporting format.
Horizon has formed a join-venture with the Cambridge Biotechnology firm Hypoxium limited that combines; novel isogenic and non-isogenic cell-based assay formats with 15 years of oncology and cell biology expertise to deliver a first-class CRO service out of a dedicated state-of-art facility.
Assay formats being routinely offered at the Hypoxium Assay Development and Screening Facility on Cambridge Science Park are:
- Proliferation Assays
- Colony Forming Assays
- Signal Transduction Assays
- Apoptosis Assays
- Invasion and Migration Assays
- Flow Cytometry
- Combination Assays
- Hypoxia Assays
Screening Services Presentation
Horizon GENESIS (Flyer)
Horizon X-MAN Isogenic Cell-lines (Flyer)
Latest X-MAN Inventory
Publications:
