Horizon’s suite of reference material includes standards for the increasing number of rare mutations being targeted for cancer therapeutics, which by definition are hard to find in clinical samples. Drawing upon rAAV GENESIS™ precision gene-editing technology, these reference materials reconstitute relevant cancer genes in human cell lines exactly as they occur in a patient’s tumor. This approach enables definition of virtually every characteristic of our reference standards, from the molecular constitution of the genome, to the diameter, width and DNA output associated with each product batch. We are also adapting this technology to serve immunohistochemistry (IHC) and fluorescent in-situ hybridization (FISH) based assays.

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